Over the past 25 years there have been few changes in the diagnosis of Alzheimer disease (AD) even though our knowledge of the disease and its progression has grown. For example, the current criteria have age cutoffs (between 40 and 90 years of age), but we know now that many people living into their 90’s […]
The results of Dr. Mitsis’s study indicate that patients with AD and MCI with and without depression share a common decrease in relative glucose activity in the temporal and parietal lobes. These are the regions of the brain that are typically affected in AD. In contrast, in the frontal lobe of the brain, a disassociation was seen with increased activity in the AD group in regions of the frontal lobe that possibly represents compensatory activation. However, patients with MCI and depression did not show this compensatory activity but instead showed a decrease, such as that often reported in mood disorders.